Name | Kasugamycin |
Synonyms | kasuminl Kasugamycin 2-(((2R,3S,5S,6R) -2-iminoacetic acid tetrahydro-2H-pyran-3-yl) -alpha-d-arabino-hexopyranosyl)- -2,3,4,5,6-pentahydroxycyclohexyl) -5-Amino-2-methyl-6-(((1R,2R,3S,4R,5S,6S) (1S,2R,3S,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl 2-amino-4-{[carboxy(imino)methyl]amino}-2,3,4,6-tetradeoxy-alpha-D-lyxo-hexopyranoside |
CAS | 6980-18-3 |
EINECS | 615-014-8 |
InChI | InChI=1/C14H25N3O9/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24)/t3-,4+,5-,6-,7+,8+,9-,10+,11+,14-/m1/s1 |
Molecular Formula | C14H25N3O9 |
Molar Mass | 379.36 |
Density | 1.2554 (rough estimate) |
Melting Point | >208°C |
Boling Point | 507.24°C (rough estimate) |
Flash Point | 308.168°C |
Solubility | Aqueous Base (Slightly), Water (Slightly) |
Vapor Presure | 0mmHg at 25°C |
Appearance | Light yellow to light beige solid |
pKa | -0.62±0.41(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.5700 (estimate) |
Physical and Chemical Properties | Its hydrochloride is a white needle-like or plate-like crystal. m.p.206 -210 °c (202-204 °c, 236-239 °c). Insoluble in methanol, ethanol, propanol, benzene and other organic solvents, soluble in water. In acidic or neutral medium is more stable, easy to destroy failure in case of alkali, under the condition of pH value 5, stored at 50 ℃ for 10 weeks, the titer did not decrease, and in the pH value of 9 conditions, the titer decreased to 42.6%. |
Use | Kasugamycin is an aminoglycoside antibiotic that inhibits protein synthesis. |
Reference Show more | 1. [IF=4.964] Zi-Qian Wang et al."A tRNA t6A modification system contributes to the sensitivity towards the toxin β-N-methylamino-L-alanine (BMAA) in the cyanobacterium Anabaena sp. PCC 7120."Aquat Toxicol. 2022 Apr;245:106121 |
with soybean cake powder, sugar, vegetable oil, yeast powder as raw materials, the pure liquid fermentation.
microbial source fungicide, mainly used for the prevention and control of rice blast, belongs to the inhalation of antibiotics, both prevention and treatment. It also has control effect on cucumber anthracnose, sorghum anthracnose and tomato leaf mold. It should not be mixed with alkaline pesticides when used.